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The play is, loosely speaking, a tragedy, with Blanche as its heroine, although she does not actually die at the end.
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Part of what makes the play a tragedy is the sense of its action unfolding in a way that comes to seem inevitable.
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The play could be said to be in the genre of Southern Gothic, focusing on death, violence, madness and decay.
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In some ways the play is a melodrama, because of its exaggerated passions and sensational plot and action.